Endocrine Abstracts

Introduction/objective: The objective was to determine if peri-operative levels of DHEAS correlate with levels of ACTH and cortisol and therefore are useful as a new marker for the definition of cure in patients suffering from Cushing’s disease. DHEAS is an ACTH-dependent precursor of androgens and estrogens secreted from the adrenals. Numerous clinical trials have shown that DHEAS in humans and other mammals is a multi-functional steroid implicated in a broad range of bi...

Cushing’s disease is caused by ACTH-secreting pituitary adenomas. Gold standard therapy is the resection of the adenoma by transsphenoidal surgery with high cure rates even in cases of negative MR imaging. Surgical failure despite clear endocrinological test results is possible and mostly explained by hidden minute adenomas within the gland.We report on a 50-year-old woman suffering from ACTH-dependent Cushing’s syndrome. Endocrinological work-...